Important
Why you start low and go slow
Titration means starting at a low dose and stepping up gradually. It's done to give your gut time to adjust, which dramatically reduces nausea and other side effects. Going too fast is the most common reason people feel awful — slowing down usually fixes it.
Ozempic (semaglutide) — weekly
Typically starts at 0.25 mg once weekly for 4 weeks (a “run-in” dose, not yet therapeutic), then 0.5 mg, with further steps to 1 mg and up to 2 mg as needed and tolerated, usually a month apart.
Wegovy (semaglutide) — weekly
A 16-week escalation: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg, increasing roughly every 4 weeks to the 2.4 mg maintenance dose, if tolerated.
Mounjaro (tirzepatide) — weekly
Starts at 2.5 mg for 4 weeks, then 5 mg, with further 2.5 mg steps every 4 weeks as needed, up to a maximum of 15 mg.
Saxenda (liraglutide) — daily
A daily injection titrated weekly: 0.6 → 1.2 → 1.8 → 2.4 → 3.0 mg, increasing each week to the 3.0 mg dose, if tolerated.
If side effects bite during a step-up
It's common to feel rougher for a few days after each increase. If it's more than that, options your provider may use include holding the current dose longer before the next step, or temporarily stepping back down. Don't increase faster than prescribed to “catch up”, and don't double a missed dose — check the leaflet or ask your provider. See managing side effects.
A registered provider sets and adjusts your titration safely
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