The quick answer
Both are semaglutide. The key differences: Wegovy is registered in SA for weight management and reaches a higher dose (2.4 mg), while Ozempic is registered for diabetes (weight-loss use is off-label) and tops out at 2 mg. For pure weight loss, Wegovy is the on-label choice; Ozempic is often used where Wegovy stock or price is a problem.
Ozempic vs Wegovy: side by side
| Feature | Ozempic | Wegovy |
|---|---|---|
| Active ingredient | Semaglutide | Semaglutide (higher dose) |
| SA registration | Type 2 diabetes | Chronic weight management |
| For weight loss | Off-label | On-label |
| Max dose | 2 mg weekly | 2.4 mg weekly |
| Avg. weight loss | Slightly less (lower max dose) | ~15% (STEP, at 2.4 mg) |
| Typical price / month | R2 700 – R3 300 | R1 900 – R3 750 (after 2026 cuts) |
| Launched in SA | Established | August 2025 |
Which might suit you
Lean Wegovy for weight loss specifically — it's registered for it, reaches the studied 2.4 mg dose, and became more competitively priced after the 2026 cuts. Lean Ozempic if it's what's available, if you have diabetes, or if a lower dose suits you. They're the same molecule, so the experience is broadly similar.
This is general information, not a recommendation for your situation. The right choice depends on your health, budget, what's in stock and a clinician's judgement. Get a personalised assessment from a registered provider
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