How-to guide

How to inject a weight-loss pen

Self-injecting feels daunting the first time and routine by the third. The needles are tiny, the pens are designed to be simple, and your provider or pharmacist will show you. Here's the general approach.

Medically reviewed by an HPCSA-registered doctor Last updated 2 sources

Note

This is general information. Always follow the instructions for your specific pen and the demonstration from your provider or pharmacist.

Before you start

  • Wash your hands.
  • Check the pen: right medicine, not expired, liquid clear (not cloudy or full of particles).
  • Attach a new needle if your pen uses screw-on tips; never reuse needles.
  • Some pens need a small “flow check” / priming step — check your leaflet.

Where to inject

These are subcutaneous injections (into the fat just under the skin), not into muscle or vein. Usual sites:

  • Abdomen — at least ~5 cm away from the belly button.
  • Front of the thighs.
  • Back of the upper arms (easier with help).

Step by step

  1. Clean the site with an alcohol swab and let it dry.
  2. Pinch a fold of skin if advised for your pen/needle length.
  3. Insert the needle (usually at 90°) and press the button to deliver the dose.
  4. Hold for the count stated in your leaflet (often ~6–10 seconds) so the full dose goes in.
  5. Withdraw, dispose of the needle safely, and note the date/dose.

Rotate your sites

Use a different spot each time (and rotate between abdomen, thigh and arm) to avoid lumps and skin changes. A simple pattern — e.g. “clockwise around the abdomen” — helps you remember.

Safe sharps disposal in SA

Never put needles in your normal bin. Use a proper sharps container (available from pharmacies); many pharmacies and clinics will take a full container back for safe disposal. Ask your pharmacist about local arrangements.

Storing your pen

These medicines need the cold chain: keep unopened pens refrigerated (typically 2–8 °C), don't freeze, and follow the leaflet on how long an in-use pen can stay at room temperature. This is also why delivery is couriered cold. Your provider or pharmacist will show you in person

Frequently asked questions

The needles are very short and fine; most people feel little or nothing. Letting the swab dry and relaxing the area helps.

The abdomen (away from the navel), front of the thighs, or back of the upper arms — rotating sites each time.

Use a sharps container from a pharmacy and return it for safe disposal; never bin loose needles.

Sources & references

We cite primary sources and paraphrase them. Last reviewed June 2026. See our editorial policy and full sources hub.

  1. 1Manufacturer Patient Information Leaflets (Novo Nordisk / Eli Lilly)Novo Nordisk; Eli Lilly. Approved dosing, administration and side-effect information.
  2. 2SAHPRA — registered health products & safety alertsSouth African Health Products Regulatory Authority. SA registration status of medicines and counterfeit / falsified-product warnings.
Next step

Thinking about treatment?

These are prescription medicines, so they are not right for everyone and can't be bought over the counter. A registered provider can assess whether one is appropriate for you, start you safely and arrange a genuine product from a licensed pharmacy.

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